Hema Upadhyay (born Hema Hirani; 1972 – 11 December 2015) was an Indian artist based in Mumbai. She was known for photography and sculptural installations. She was active from 1998 until her death in 2015.

Born Hema Hirani in Baroda, she met her future husband and fellow artist Chintan Upadhyay in 1992. The couple married in 1998, and settled in Mumbai. They worked together in many exhibitions, before filing for a divorce in 2010. They were officially divorced in 2014. Chintan then moved to Delhi; she lived in their flat on the Juhu-Tara road.

Hema had her first solo exhibition, titled Sweet Sweat Memories, at Gallery Chemould, now Chemould Prescott road (Mumbai), in 2001. The exhibition consisted of mixed media on paper works. In these works she has incorporated her own photographs to communicate her ideas of migration having moved to Bombay in 1998. Hema's paintings were usually characterised by the inclusion of small-collaged photographic self-portraits.